AG Prof. Dr.-Ing. Jens Hartung
The working group deals with synthetic and methodological questions of oxygen chemistry.
The focus is on the systematics of polar influences on oxygen on reactivity and selectivity for forming or breaking oxygen-carbon bonds. The working group approaches this logic through kinetic, thermochemical and theoretical investigations of oxygen radical reactions, aerobic oxidation and peroxide-based chemical transformations.
The subject area "oxidations" includes peroxidase-mediated processes as well as those with synthetic vanadium-, molybdenum-, titanium- and cobalt-based catalysts.
From the systematics of oxygen radical-based reactions, the group attempts to derive principles that can be used to predict atmospheric, biosynthetic and medical reaction pathways of hydroxyl, alkoxyl and aryloxyl radicals for syntheses or therapies. In this way, the group plans to reach reaction channels that are not accessible to polar reactions or only accessible in a roundabout way.
AG Prof. Dr. Stefan Kubik
The main research area of the working group is supramolecular chemistry. In this context, an important research topic is the development of synthetic anion receptors, whereby most of the receptors investigated are based on cyclic peptides and pseudopeptides.
Of particular interest is the recognition of anions in water and the understanding of the underlying principles. In addition to macrocyclic receptors, gold nanoparticles and polymeric materials have recently been used for anion binding.
A completely different research topic, but one that is also part of supramolecular chemistry, is the development of compounds that convert neurotoxic organophosphates into non-toxic metabolites so quickly under physiological conditions that they can be used to treat poisoning with these neurotoxins.
AG Prof. Dr. Georg Manolikakes
Our research activities focus on the development of new processes that enable the efficient and at the same time highly modular synthesis of complex molecular structures. A special focus here is on the representation of pharmacologically relevant structural motifs. In order to realize methods that are as widely applicable and easy to carry out as possible, we very often use the concept of one-pot and multicomponent reactions.
The Manolikakes group is currently working on the following projects:
- Sulfur dioxide-based multicomponent reactions for the synthesis of sulfones and sulfonamides
- Imine-based multicomponent reactions for the stereoselective and sustainable synthesis of amines and amino acids
- Enamide-based reaction sequences for the highly stereoselective synthesis of complex nitrogen-containing organic molecules
- Nitrated fatty acids as lead structures for the development of new drugs
Organic chem. Colloquium
Here you will find an overview of the lectures at the Organic Chemistry Colloquium. Guests are very welcome. If you would like to be informed regularly about our colloquium, you are welcome to subscribe to the e-mail distribution list in our secretariat (Ms. Zeigner - e-mail contact).