The working group deals with synthetic and methodological questions of oxygen chemistry.

The focus is on the systematics of polar influences on oxygen on reactivity and selectivity for forming or breaking oxygen-carbon bonds. The working group approaches this logic through kinetic, thermochemical and theoretical investigations of oxygen radical reactions, aerobic oxidation and peroxide-based chemical transformations.

The topic of "oxidations" includes peroxidase-mediated processes as well as those with synthetic vanadium-, molybdenum-, titanium- and cobalt-based catalysts. In terms of method development, the group focuses on investigating reactions that support the transition to more sustainable processes in order to preserve the earth's resources for future generations.

From the systematics of oxygen radical-based reactions , the group seeks to derive principles to predict atmospheric, biosynthetic and medical reaction pathways of hydroxyl, alkoxyl and aryloxyl radicals for syntheses or therapies. In this way, the group plans to reach reaction channels that are not accessible to polar reactions or only accessible in a roundabout way.

A) Oxygen-centered Radicals

A1) Natural Product Chemistry - Synthesis and Structural Characterization of the Isomuscarines
A2) Mechanistic Investigation - On Selectivity Control by Polar Substituent Effects

B) Vanadium-, Molybdenum-, Titanium- and Cobalt-catalyzed Oxidation

B1) Vanadium-catalyzed Oxidation - Part I
B2) Vanadium-catalyzed Oxidation - Part II

C) Marine bromoperoxidase

C1) Vanadate-dependent Bromoperoxidase
C2) Functional Model of Bromoperoxidase
C3) X-Ray-Diffraction and Density Functional Theory - Bromoperoxidase II

D) Aerobic Oxidation

STRUCTURAL AND COMPUTATIONAL CHEMISTRY

E )Structural Chemistry

F) Conformational Analysis

G) Computational Chemistry