Supervisor: M. Deponte

Course: See here

Term: WiSe/SuSe

Content:

Selected current biochemical research in enzymology and/or molecular parasitology, e.g., methods in molecular biology, cell culture, CRISPR-Cas9 genetics, western blot analysis, protein purification, steady-state and/or stopped-flow enzyme kinetic measurements. The exact content of the practical module depends on current research activities. 

If you are interested in a practical course, feel free to contact members of the lab or reach out directly to Marcel Deponte via email. Please note that supervision capacity and internship opportunities are limited, so early planning is strongly recommended.

Supervisor: M. Deponte

Course: See here

Term: WiSe/SuSe

Content:

Selected current biochemical research methods in enzymology and protein structure-function analyses. The exact content of the practical module depends on current research activities. 

If you are interested in a practical course, feel free to contact members of the lab or reach out directly to Marcel Deponte via email. Please note that supervision capacity and internship opportunities are limited, so early planning is strongly recommended.

Lecturer: M. Deponte

Course: See here

Term: Summer semester

Venue & Time:

HS 52-207 / Mon 8⁴⁵ - 9³⁰ 

HS 52-204 / Tue 10¹⁵ - 11⁴⁵

Content:

• Advanced amino acid metabolism (rep. amino acids, enzyme mechanisms, connections with carbon metabolism, mediators/hormons/neurotransmitters, nitrogen excretion)
• Protein structure (rep. primary to quaternary structure, folding problem, structure-function relationships)
• Intracellular protein turnover (synthesis, folding, sorting, secondary modifications, degradation)
• Protein production and purification (methods in research & industry)

OpenOlat Material: See here

Lecturer: M. Deponte

Course: See here

Term: Summer semester

Venue & Time:

Room 54-582 / flexible

Content:

• Overview and phylogeny of parasitic protists
• Special cell organelles and metabolic pathways
• Molecular parasitology
• Chemical and genetic rescue strategies
• Drug development (screening vs. rational drug design, target identification)
• Resistance mechanisms
• Current parasite/pathway/drug study of choice

OpenOlat Material: See here

Lecturer: M. Deponte

Course: See here

Term: Winter semester

Venue & Time:

HS 52-204 / Mon 12¹⁵ - 13⁴⁵ 

HS 46-280 / Wed 8⁴⁵ - 9³⁰

Content:

• Introduction (organismic diversity, metabolic compartmentalization)
• Comparison of metabolic pathways (examples of analogous & differing reactions, purine and pyrimidine metabolism)
• Model systems and applications (eukaryotic and prokaryotic model systems, molecular tools)
• Comparison of pro- and eukaryotes (energy metabolism, information systems, growth and reproduction, optional: defence & immune systems or motility)

OpenOlat Material: See here

Lecturer: M. Deponte

Course: See here

Term: Winter semester

Venue & Time:

Room 54-582 / Tue 9⁰⁰ - 10⁴⁵ 

Content:

• Enzyme classification
• Principles of enzyme catalysis
• Steady-state and pre-steady state kinetics
• Enzyme inhibitors
• Allostery and cooperativity
• Data analysis and evaluation
• Selected enzyme mechanisms and examples

OpenOlat Material: See here