Data analysis:

Expasy-tools

Sequence manipulation suite

Swiss-model server

Alphafold

NCBI BLAST

Multiple sequence alignments

HHPRED

Protocols:

Centrifuge parameters

Cold Spring Harbor Protocols

Literature:

Entrez PubMed

Scopus

Nature

Science

Biochemistry

JBC

Microbial Cell

Mol & Biochem Parasitol

Enzyme kinetics

Databases:

PDB Protein Data Bank

SGD Yeast Database

Yeast Deletion and Mitochondrial Proteomics

Yeast Chemogenomics Database

Plasmodium Database Plasmo DB

Plasmodium Phenoplasm Database

Malaria Parasite Metabolic Pathways

LeishGEdit

Parasite Database EuPathDB

Welcome Sanger Gene DB

Protozoan Genomes

IUBMB Nomenclature

Societies:

GBM Gesellschaft für Biochemie und Molekularbiologie

Deutsche Gesellschaft für Parasitologie

DFG Deutsche Forschungsgemeinschaft

Others:

Leo English/German Dictionary

Parasite of the Day

The Malaria Comic

Lecturer: M. Deponte

Course: See here

Term: Summer semester

Venue & Time:

HS 52-207 / Mon 8⁴⁵ - 9³⁰ 

HS 52-204 / Tue 9⁰⁰ - 10³⁰

Content:

• Advanced amino acid metabolism (rep. proteinogenic amino acids, enzyme mechanisms, connections with carbon metabolism, mediators/hormons/neurotransmitters, nitrogen excretion)

• Protein structure (rep. primary to quaternary structure, folding problem, structure-function relationships)

• Intracellular protein turnover (synthesis, folding, sorting, secondary modifications, degradation)

• Protein production and purification (methods in research & industry)

OpenOlat Material: See here

Lecturer: M. Deponte

Course: See here

Term: Summer semester

Venue & Time:

To be announced 

Content:

• Overview and phylogeny of parasitic protists

• Special cell organelles and metabolic pathways

• Molecular parasitology

• Drug development (screening vs. rational drug design, target identification)

• Resistance mechanisms

OpenOlat Material: See here

Lecturer: M. Deponte

Course: See here

Term: Winter semester

Venue & Time:

HS 13-222 / Mon 11⁴⁵ - 13¹⁵ 

HS 46-280 / Wed 8⁴⁵ - 9³⁰

Content:

• Introduction (organismic diversity, metabolic compartmentalization)

• Comparison of metabolic pathways (examples of analogous & differing reactions, purine and pyrimidine metabolism)

• Model systems and applications (eukaryotic and prokaryotic model systems, molecular tools)

• Comparison of pro- and eukaryotes (energy metabolism, information systems, growth and reproduction, optional: defence & immune systems or motility)

OpenOlat Material: See here

Lecturer: M. Deponte

Course: See here

Term: Winter semester

Venue & Time:

Room 54-582 / Tue 9⁰⁰ - 10⁴⁵ 

Content:

• Enzyme classification

• Principles of enzyme catalysis

• Steady-state and pre-steady state kinetics

• Reversible and irreversible reactions

• Enzyme inhibitors

• Allostery and cooperativity

• Data analysis and evaluation

• Selected enzyme mechanisms and examples

OpenOlat Material: See here